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a list of diuretic medications (naproxen and ibuprofen) in a randomized trial of 20,000 high risk patients that is due to begin in 2006 (PRECISION study sponsored by Pfizer) A recent meta-analysis of all trials comparing non-steroidal anti-inflammatory drugs found a 80% increase in the risk of myocardial infarction with both newer Cox-2 antagonists and high dose traditional anti-inflammatories compared with placebo, with the important exception of naproxen, which was not associated with an increased cardiovascular risk (Kearney et al, BMJ 2006;332:1302-1308)
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